ORC6

Across TCGA pan-cancer cohorts, ORC6 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of ORC6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ORC6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ORC6 is over-expressed in tumor.

HNSC, BLCA, and LUAD are the cancer types where ORC6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ORC6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.903	<.001	12	view →
BLCA	All	IV	+2.578	<.001	11	view →
LUAD	Male	III,IV	+2.393	<.001	11	view →
COAD	Female	III,IV	+2.028	<.001	11	view →
KIRP	All	III,IV	+1.549	<.001	11	view →
THCA	Male	III,IV	+0.651	<.001	11	view →
STAD	Female	All	+1.770	<.001	9	view →
LIHC	Female	II,III,IV	+1.092	<.001	9	view →
KIRC	Male	IV	+0.675	<.001	9	view →
UCEC	All	III,IV	+3.172	<.001	8	view →
LUSC	Male	III,IV	+2.997	<.001	8	view →
READ	All	II,III,IV	+2.032	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

ORC6–HNSC

Open the HNSC breakdown →