ORC6

Across TCGA patient cohorts, ORC6 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ORC6-associated genes across cancer lineages are PRAS40_pT246, Caspase-8, and CD49b. Each is linked with ORC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORC6-to-partner and partner-to-ORC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by ORC6-low versus ORC6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC6→partner) and Y-score (partner→ORC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.217	+2.335	.012	.020	3	1
UCEC	Caspase-8 →	-0.261	-3.459	.039	.005	3	1
UCEC	CD49b →	-0.342	-2.308	.016	.036	3	1
UCEC	Chk2 →	-0.237	-2.321	.044	.035	3	1
UCEC	Tuberin →	+0.339	+3.459	.012	.005	2	1
UCEC	p27_pT198 →	+0.133	+2.321	.013	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PRAS40_pT246 by ORC6 expression — UCEC

Explore this box plot interactively →