ORC6

Across TCGA cell cohorts, ORC6 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,348 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ORC6-associated GO terms across cancer lineages are Recombinational repair, Positive regulation of cell cycle process, and Regulation of DNA-templated DNA replication. Each is linked with ORC6 in more than 19 cancer types. Because this analysis shows association rather than direction, both ORC6-to-partner and partner-to-ORC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Recombinational repair grouped by ORC6-low versus ORC6-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC6→partner) and Y-score (partner→ORC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Recombinational repair →	+0.115	+1.691	<.001	<.001	3	20
BONE	Positive regulation of cell cycle process →	+0.113	+1.317	.004	.006	3	20
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated DNA replication →	+0.139	+1.351	<.001	<.001	3	20
OESOPHAGUS	DNA replication →	+0.137	+1.518	<.001	<.001	3	20
OESOPHAGUS	DNA-templated DNA replication →	+0.142	+1.518	<.001	<.001	3	20
LUNG_NSCLC_LUSC	DNA replication initiation →	+0.170	+1.153	<.001	.002	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,348 associations by consensus.

Recombinational repair by ORC6 expression — OESOPHAGUS

Explore this box plot interactively →