ORC4

Across TCGA pan-cancer cohorts, ORC4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ORC4 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ORC4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ORC4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where ORC4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.475	1.000	.016	22	view →
CCRCC	DFS	Tertile	All	1.000	0.476	.006	10	view →
LSCC	OS	Quartile	II,III,IV	0.941	0.664	.016	6	view →
LUAD	DFS	Tertile	III,IV	0.996	0.517	.018	5	view →
PDAC	DFS	Median	All	0.600	0.840	.015	3	view →
GBM	OS	Tertile	All	0.782	0.878	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ORC4–HNSC (DFS)

Open the HNSC breakdown →