ORC4

Across TCGA pan-cancer cohorts, ORC4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ORC4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ORC4 RNA is repressed in tumor relative to normal tissue. In most cancer types ORC4 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LIHC are the cancer types where ORC4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ORC4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.402	<.001	10	view →
KICH	Female	II,III,IV	−1.742	<.001	9	view →
LIHC	All	III,IV	+0.577	<.001	9	view →
HNSC	Male	III,IV	+0.523	.002	8	view →
KIRC	Male	III,IV	−0.458	.001	6	view →
BLCA	All	All	+0.334	.004	6	view →
LUAD	All	All	+0.269	<.001	6	view →
CHOL	All	All	+1.718	<.001	5	view →
STAD	All	II,III,IV	+0.520	.001	4	view →
COAD	Male	All	+0.351	.003	4	view →
KIRP	All	IV	+0.479	.012	2	view →
LUSC	All	All	+0.283	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ORC4–THCA

Open the THCA breakdown →