ORC4

Across TCGA patient cohorts, ORC4 mutation is significantly associated with the RNA expression of many other genes, with 1,041 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ORC4-associated genes across cancer lineages are OR9M1P, RNA5SP21, and RNF19BPX. Each is linked with ORC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORC4-to-partner and partner-to-ORC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9M1P grouped by ORC4-low versus ORC4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC4→partner) and Y-score (partner→ORC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR9M1P →	+0.175	+3.942	.004	.003	3	2
SKCM	RNA5SP21 →	+0.421	+3.630	<.001	.004	3	2
SKCM	RNF19BPX →	+0.037	+4.624	<.001	.005	3	2
BRCA	MIR6853 →	+0.364	+9.057	<.001	.003	3	1
CESC	FMO10P →	+0.064	+5.306	<.001	.006	3	1
CESC	CCND3P2 →	+0.077	+6.569	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,041 associations by consensus.

OR9M1P by ORC4 expression — SKCM

Explore this box plot interactively →