ORC4

Across TCGA patient cohorts, ORC4 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ORC4-associated genes across cancer lineages are MEK1, MSH2, and MSH6. Each is linked with ORC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORC4-to-partner and partner-to-ORC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ORC4-low versus ORC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC4→partner) and Y-score (partner→ORC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.429	+3.459	.002	.005	3	1
UCEC	MSH2 →	-0.272	-1.973	.002	.029	3	1
UCEC	MSH6 →	-0.317	-3.169	.012	.018	3	1
UCEC	Notch1 →	+0.212	+3.594	<.001	.001	3	1
UCEC	p27_pT198 →	+0.115	+1.678	.004	.023	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.389	-1.700	.024	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MEK1 by ORC4 expression — UCEC

Explore this box plot interactively →