ORC4

Across TCGA cell cohorts, ORC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,757 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ORC4-associated GO terms across cancer lineages are Nuclear pore organization, Mitotic spindle assembly, and 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process. Each is linked with ORC4 in more than 13 cancer types. Because this analysis shows association rather than direction, both ORC4-to-partner and partner-to-ORC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear pore organization grouped by ORC4-low versus ORC4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC4→partner) and Y-score (partner→ORC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Nuclear pore organization →	+0.180	+1.190	<.001	<.001	3	14
OVARY	Mitotic spindle assembly →	+0.090	+0.412	.001	.007	3	13
LUNG_SCLC	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process →	+0.106	+0.582	<.001	.007	3	13
LUNG_SCLC	Regulation of microtubule-based process →	+0.054	+0.527	<.001	<.001	3	13
LUNG_SCLC	Regulation of centrosome cycle →	+0.074	+0.493	<.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of RNA export from nucleus →	+0.124	+0.994	.003	.008	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,757 associations by consensus.

Nuclear pore organization by ORC4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →