ORC4

Across TCGA cell cohorts, ORC4 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ORC4-associated genes across cancer lineages are AQP12A and GSG1L2. Each is linked with ORC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORC4-to-partner and partner-to-ORC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP12A grouped by ORC4-low versus ORC4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC4→partner) and Y-score (partner→ORC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AQP12A →	+0.179	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

AQP12A by ORC4 expression — BLOOD_Leukemia

Explore this box plot interactively →