ORC2

Across TCGA patient cohorts, ORC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,768 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ORC2-associated proteins across cancer lineages are ORC3, ILKAP, and NELFB. Each is linked with ORC2 in more than 6 cancer types. Because this analysis shows association rather than direction, both ORC2-to-partner and partner-to-ORC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ORC2 versus ORC3 in LSCC, with a Pearson correlation of 0.70.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC2→partner) and Y-score (partner→ORC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ORC3 →	+0.449	+0.611	<.001	<.001	3	7
UCEC	ILKAP →	+0.315	+0.359	<.001	.004	3	7
GBM	NELFB →	+0.263	+0.224	<.001	<.001	3	6
LSCC	NUP205 →	+0.196	+0.486	<.001	<.001	3	6
GBM	NUP93 →	+0.179	+0.284	<.001	<.001	3	6
LSCC	ORC4 →	+0.386	+0.590	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,768 associations by consensus.

ORC2 vs ORC3 — LSCC

Explore this scatter interactively →