ORC2

Across TCGA patient cohorts, ORC2 mutation is significantly associated with the RNA expression of many other genes, with 2,364 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ORC2-associated genes across cancer lineages are P3R3URF-PIK3R3, RNU6-1318P, and PSMD14P1. Each is linked with ORC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORC2-to-partner and partner-to-ORC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P3R3URF-PIK3R3 grouped by ORC2-low versus ORC2-high in KIRP.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC2→partner) and Y-score (partner→ORC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	P3R3URF-PIK3R3 →	+0.040	+4.497	<.001	.009	3	2
UCEC	RNU6-1318P →	+0.229	+2.288	<.001	.004	3	2
UCEC	PSMD14P1 →	+0.087	+1.501	.005	.007	3	2
LUSC	RNU4-58P →	+0.281	+5.148	<.001	.002	3	2
LUSC	PRR23A →	+0.169	+4.031	<.001	.004	3	2
LUSC	RN7SL794P →	+0.128	+3.849	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,364 associations by consensus.

P3R3URF-PIK3R3 by ORC2 expression — KIRP

Explore this box plot interactively →