ORC1

Across TCGA patient cohorts, ORC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 24,229 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ORC1-associated proteins across cancer lineages are RFC1_T506, RFC2, and RRM1. Each is linked with ORC1 in more than 9 cancer types. Because this analysis shows association rather than direction, both ORC1-to-partner and partner-to-ORC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ORC1 versus RFC1_T506 in LUAD, with a Pearson correlation of 0.71.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC1→partner) and Y-score (partner→ORC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RFC1_T506 →	+1.169	+1.121	<.001	<.001	3	10
LSCC	RFC2 →	+0.424	+0.794	<.001	<.001	3	10
OV	RRM1 →	+0.554	+0.912	<.001	.004	3	10
LUAD	RRM2 →	+0.931	+1.148	<.001	<.001	3	10
GBM	SMC2 →	+0.805	+1.039	<.001	<.001	3	10
GBM	SMC4 →	+0.751	+1.007	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 24,229 associations by consensus.

ORC1 vs RFC1_T506 — LUAD

Explore this scatter interactively →