ORC1

Across TCGA patient cohorts, ORC1 protein abundance is significantly associated with the RNA expression of many other genes, with 7,686 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ORC1-associated genes across cancer lineages are TTK, KIF14, and CENPF. Each is linked with ORC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ORC1-to-partner and partner-to-ORC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ORC1 versus TTK in BRCA, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC1→partner) and Y-score (partner→ORC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTK →	+1.338	+0.372	<.001	<.001	3	6
GBM	KIF14 →	+1.166	+0.479	<.001	<.001	3	6
UCEC	CENPF →	+1.352	+0.447	.006	.007	3	5
BRCA	BUB1B →	+1.047	+0.325	<.001	.003	3	5
UCEC	SKA3 →	+1.220	+0.500	<.001	.002	3	5
GBM	CDT1 →	+0.951	+0.542	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,686 associations by consensus.

ORC1 vs TTK — BRCA

Explore this scatter interactively →