ORC1

Across TCGA cell cohorts, ORC1 mutation is significantly associated with the RNA expression of many other genes, with 501 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ORC1-associated genes across cancer lineages are DUSP21, SLC5A8, and CBLN4. Each is linked with ORC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORC1-to-partner and partner-to-ORC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DUSP21 grouped by ORC1-low versus ORC1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC1→partner) and Y-score (partner→ORC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DUSP21 →	+0.061	+5.000	<.001	.006	3	1
PANCREAS	SLC5A8 →	+0.006	+5.614	<.001	.002	3	1
PANCREAS	CBLN4 →	+0.006	+5.614	<.001	.002	3	1
URINARY_TRACT	LY6G6F →	+0.040	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	SLC17A2 →	+0.016	+6.266	<.001	<.001	3	1
SKIN	GLT6D1 →	+0.012	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 501 associations by consensus.

DUSP21 by ORC1 expression — PANCREAS

Explore this box plot interactively →