ORAI3

Across TCGA patient cohorts, ORAI3 protein abundance is significantly associated with the RNA expression of many other genes, with 156 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ORAI3-associated genes across cancer lineages are RASL10A, MTHFD1, and PSMD10. Each is linked with ORAI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORAI3-to-partner and partner-to-ORAI3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ORAI3 versus RASL10A in LSCC, with a Pearson correlation of 0.78.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORAI3→partner) and Y-score (partner→ORAI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RASL10A →	+0.285	+0.470	.003	.007	3	1
LSCC	MTHFD1 →	-0.729	-0.563	<.001	<.001	3	1
LSCC	PSMD10 →	-0.529	-0.605	.001	.005	3	1
LSCC	POLE4 →	-0.862	-0.654	<.001	.002	3	1
LSCC	ONECUT2 →	-1.440	-0.518	.008	.002	3	1
LSCC	TNN →	+0.530	+0.512	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 156 associations by consensus.

ORAI3 vs RASL10A — LSCC

Explore this scatter interactively →