ORAI1

Across TCGA cell cohorts, ORAI1 mutation is significantly associated with the mutation status of many other genes, with 2,118 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ORAI1-associated genes across cancer lineages are FMR1, HOMER1, and SVEP1. Each is linked with ORAI1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ORAI1-to-partner and partner-to-ORAI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FMR1 grouped by ORAI1-low versus ORAI1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORAI1→partner) and Y-score (partner→ORAI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FMR1 →	+5.285	+4.321	.005	.005	1	4
BLOOD_Lymphoma	HOMER1 →	+5.584	+5.014	.003	.003	1	4
BLOOD_Leukemia	SVEP1 →	+2.825	+3.847	.001	.001	1	4
BLOOD_Lymphoma	TEAD1 →	+5.584	+5.014	.003	.003	1	4
OVARY	CARM1 →	+4.217	+4.217	.001	.001	1	4
LARGE_INTESTINE	HSD17B14 →	+5.523	+5.523	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,118 associations by consensus.

FMR1 by ORAI1 expression — BLOOD_Leukemia

Explore this box plot interactively →