OR8U1

Across TCGA patient cohorts, OR8U1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR8U1-associated genes across cancer lineages are Cyclin-B1, PREX1, and Shc_pY317. Each is linked with OR8U1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR8U1-to-partner and partner-to-OR8U1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by OR8U1-low versus OR8U1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8U1→partner) and Y-score (partner→OR8U1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+1.002	+3.459	<.001	.005	3	2
UCEC	PREX1 →	-0.306	-2.999	.016	.035	3	2
UCEC	Shc_pY317 →	-0.238	-2.321	<.001	.033	3	2
UCEC	VEGFR2 →	+0.395	+3.321	.004	.009	3	2
LUAD	MIG-6 →	+0.211	+3.169	.035	.018	3	1
UCEC	14-3-3_beta →	-0.130	-3.143	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Cyclin-B1 by OR8U1 expression — UCEC

Explore this box plot interactively →