OR8K5

Across TCGA cell cohorts, OR8K5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible OR8K5-associated genes across cancer lineages are ADH4, KLK9, and TDRD15. Each is linked with OR8K5 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR8K5-to-partner and partner-to-OR8K5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADH4 grouped by OR8K5-low versus OR8K5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8K5→partner) and Y-score (partner→OR8K5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ADH4 →	+0.139	+4.095	<.001	.009	3	1
LUNG_NSCLC_LUAD	KLK9 →	+0.103	+4.215	<.001	.002	3	1
LUNG_NSCLC_LUAD	TDRD15 →	+0.361	+3.734	<.001	.006	3	1
LUNG_SCLC	OR14I1 →	+0.163	+4.070	<.001	.003	3	1
BREAST	DEFA4 →	+0.046	+5.781	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ADH4 by OR8K5 expression — SKIN

Explore this box plot interactively →