OR8K1

Across TCGA patient cohorts, OR8K1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR8K1-associated genes across cancer lineages are FoxM1, TFRC, and A-Raf_pS299. Each is linked with OR8K1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR8K1-to-partner and partner-to-OR8K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by OR8K1-low versus OR8K1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8K1→partner) and Y-score (partner→OR8K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.260	+1.807	.015	.027	3	3
UCEC	TFRC →	+0.624	+3.321	.004	.010	3	3
UCEC	A-Raf_pS299 →	-0.159	-3.700	.001	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.186	-2.308	.007	.006	3	2
UCEC	Notch1 →	+0.124	+1.807	.032	.027	3	2
UCEC	Shc_pY317 →	-0.237	-3.459	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

FoxM1 by OR8K1 expression — UCEC

Explore this box plot interactively →