OR8K1

Across TCGA cell cohorts, OR8K1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible OR8K1-associated genes across cancer lineages are GAPDH, NF2, and NF-kB-p65_pS536. Each is linked with OR8K1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR8K1-to-partner and partner-to-OR8K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by OR8K1-low versus OR8K1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8K1→partner) and Y-score (partner→OR8K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GAPDH →	+0.871	+2.871	.034	.021	3	1
LUNG_SCLC	NF2 →	+0.530	+2.871	.011	.021	3	1
LUNG_SCLC	NF-kB-p65_pS536 →	+0.709	+2.871	.017	.021	3	1
LUNG_SCLC	Smad1 →	-0.192	-2.743	.027	.046	3	1
LUNG_SCLC	Bcl-2 →	-0.945	-2.743	.025	.046	3	1
LUNG_SCLC	MSH2 →	-0.455	-2.743	.008	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GAPDH by OR8K1 expression — LUNG_SCLC

Explore this box plot interactively →