OR8I2

Across TCGA patient cohorts, OR8I2 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR8I2-associated genes across cancer lineages are PDCD4, PKC-b-II_pS660, and MEK1. Each is linked with OR8I2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR8I2-to-partner and partner-to-OR8I2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by OR8I2-low versus OR8I2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8I2→partner) and Y-score (partner→OR8I2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PDCD4 →	-0.532	-2.557	.002	.011	3	2
LUSC	PKC-b-II_pS660 →	-0.288	-3.000	.034	.035	3	2
UCEC	MEK1 →	+0.363	+1.906	.013	.016	3	2
UCEC	VHL →	-0.950	-2.700	<.001	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.720	+1.906	.002	.016	3	2
LUSC	N-Cadherin →	+0.137	+3.188	.026	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

PDCD4 by OR8I2 expression — LUSC

Explore this box plot interactively →