OR8I2

Across TCGA cell cohorts, OR8I2 mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible OR8I2-associated genes across cancer lineages are RAMP3, IQCF5, and RXFP2. Each is linked with OR8I2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR8I2-to-partner and partner-to-OR8I2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAMP3 grouped by OR8I2-low versus OR8I2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8I2→partner) and Y-score (partner→OR8I2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RAMP3 →	+0.306	+2.556	<.001	.007	3	2
LUNG_NSCLC_LUAD	IQCF5 →	+0.030	+3.189	.006	.007	3	2
SOFT_TISSUE	RXFP2 →	+0.833	+3.736	<.001	.008	3	1
SOFT_TISSUE	PLCZ1 →	+0.285	+3.736	.003	.008	3	1
SOFT_TISSUE	NLRP5 →	+0.134	+3.736	<.001	.008	3	1
SOFT_TISSUE	ODF3 →	+0.019	+4.237	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

RAMP3 by OR8I2 expression — BLOOD_Leukemia

Explore this box plot interactively →