OR8H2

Across TCGA cell cohorts, OR8H2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible OR8H2-associated genes across cancer lineages are OR5H8, HSF5, and MAGEB5. Each is linked with OR8H2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR8H2-to-partner and partner-to-OR8H2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5H8 grouped by OR8H2-low versus OR8H2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8H2→partner) and Y-score (partner→OR8H2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR5H8 →	+0.012	+4.437	<.001	.004	3	2
OESOPHAGUS	HSF5 →	+0.007	+4.857	<.001	<.001	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUAD	OPN1LW →	+0.038	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	PRSS55 →	+0.021	+3.695	<.001	.005	3	1
LUNG_NSCLC_LUAD	C1orf185 →	+0.042	+3.887	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR5H8 by OR8H2 expression — SKIN

Explore this box plot interactively →