OR8G5

Across TCGA patient cohorts, OR8G5 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR8G5-associated genes across cancer lineages are mTOR_pS2448, NDRG1_pT346, and YAP_pS127. Each is linked with OR8G5 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR8G5-to-partner and partner-to-OR8G5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by OR8G5-low versus OR8G5-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8G5→partner) and Y-score (partner→OR8G5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	mTOR_pS2448 →	-0.288	-3.000	.005	.036	3	1
LUAD	NDRG1_pT346 →	-0.716	-3.000	.018	.036	3	1
LUAD	YAP_pS127 →	-0.609	-3.000	.002	.036	3	1
LUAD	ASNS →	+0.759	+3.000	.002	.036	3	1
LUAD	YAP →	-0.255	-3.000	.038	.036	3	1
LUAD	beta-Catenin →	-0.557	-3.000	.034	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

mTOR_pS2448 by OR8G5 expression — LUAD

Explore this box plot interactively →