OR8B12

Across TCGA patient cohorts, OR8B12 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR8B12-associated genes across cancer lineages are p62 Lck ligand, TIGAR, and ER-alpha. Each is linked with OR8B12 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR8B12-to-partner and partner-to-OR8B12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by OR8B12-low versus OR8B12-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR8B12→partner) and Y-score (partner→OR8B12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	p62 Lck ligand →	+0.476	+2.186	.037	.034	2	3
UCEC	TIGAR →	+0.211	+2.833	.024	.035	3	2
SKCM	ER-alpha →	-0.194	-3.572	.009	.002	3	2
SKCM	MIG-6 →	+0.198	+2.025	.001	.016	3	2
SKCM	PDCD4 →	-0.350	-1.700	.029	.040	3	2
SKCM	TFRC →	+0.694	+3.321	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

p62 Lck ligand by OR8B12 expression — LUAD

Explore this box plot interactively →