OR6F1

Across TCGA patient cohorts, OR6F1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR6F1-associated genes across cancer lineages are Dvl3, PDK1_pS241, and Stathmin. Each is linked with OR6F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR6F1-to-partner and partner-to-OR6F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dvl3 grouped by OR6F1-low versus OR6F1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR6F1→partner) and Y-score (partner→OR6F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Dvl3 →	+0.223	+2.321	.015	.035	3	2
UCEC	PDK1_pS241 →	+0.181	+2.335	.035	.020	3	2
UCEC	Stathmin →	+0.159	+2.321	.021	.035	3	2
LUAD	IRS1 →	+0.128	+3.000	.023	.034	3	1
LUSC	EGFR →	+0.307	+2.340	.042	.017	3	1
LUSC	PREX1 →	-0.196	-1.798	.006	.026	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Dvl3 by OR6F1 expression — UCEC

Explore this box plot interactively →