OR6C4

Across TCGA patient cohorts, OR6C4 mutation is significantly associated with the RNA expression of many other genes, with 572 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR6C4-associated genes across cancer lineages are SGTA, MAP2K2, and PIN1. Each is linked with OR6C4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR6C4-to-partner and partner-to-OR6C4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SGTA grouped by OR6C4-low versus OR6C4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR6C4→partner) and Y-score (partner→OR6C4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SGTA →	+0.334	+2.686	.002	.004	3	2
SKCM	MAP2K2 →	+0.390	+3.845	<.001	<.001	3	2
SKCM	PIN1 →	+0.303	+1.743	.006	.004	3	2
SKCM	SPATA2L →	+0.395	+2.102	.003	<.001	3	2
UCEC	TRIM17 →	-1.378	-3.574	.001	.003	3	2
UCEC	DOHH →	+0.555	+3.202	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 572 associations by consensus.

SGTA by OR6C4 expression — SKCM

Explore this box plot interactively →