OR6C4

Across TCGA cell cohorts, OR6C4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible OR6C4-associated genes across cancer lineages are SEMG1, OR4F4, and CCDC172. Each is linked with OR6C4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR6C4-to-partner and partner-to-OR6C4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMG1 grouped by OR6C4-low versus OR6C4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR6C4→partner) and Y-score (partner→OR6C4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SEMG1 →	+0.015	+4.169	<.001	.001	3	1
LUNG_SCLC	OR4F4 →	+0.010	+4.058	<.001	.007	3	1
LUNG_SCLC	CCDC172 →	+0.222	+3.523	.002	.008	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1
LUNG_SCLC	DTHD1 →	+0.034	+3.523	<.001	.008	3	1
LUNG_SCLC	PRAMEF20 →	+0.296	+4.684	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SEMG1 by OR6C4 expression — LUNG_SCLC

Explore this box plot interactively →