OR6B3

Across TCGA patient cohorts, OR6B3 mutation is significantly associated with the RNA expression of many other genes, with 3,276 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR6B3-associated genes across cancer lineages are AZI2, SLK, and RAD18. Each is linked with OR6B3 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR6B3-to-partner and partner-to-OR6B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZI2 grouped by OR6B3-low versus OR6B3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR6B3→partner) and Y-score (partner→OR6B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AZI2 →	+0.717	+3.343	<.001	<.001	3	3
UCEC	SLK →	+0.656	+2.831	<.001	.001	3	3
SKCM	RAD18 →	+0.690	+3.604	.003	.001	3	3
UCEC	XPNPEP1 →	+0.469	+2.662	.001	<.001	3	3
UCEC	NUP155 →	+0.508	+2.338	.005	.003	3	3
CESC	PABPC5-AS1 →	+0.194	+3.760	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,276 associations by consensus.

AZI2 by OR6B3 expression — UCEC

Explore this box plot interactively →