OR5K1

Across TCGA patient cohorts, OR5K1 mutation is significantly associated with the RNA expression of many other genes, with 1,638 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR5K1-associated genes across cancer lineages are RITA1, DEFB125, and RNA5SP40. Each is linked with OR5K1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR5K1-to-partner and partner-to-OR5K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RITA1 grouped by OR5K1-low versus OR5K1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5K1→partner) and Y-score (partner→OR5K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RITA1 →	+0.511	+3.855	<.001	<.001	3	3
BLCA	DEFB125 →	+0.048	+4.588	.002	.008	3	3
GBM	RNA5SP40 →	+0.704	+4.969	<.001	.009	3	2
UCEC	NOP10 →	+0.445	+3.757	.002	<.001	3	2
UCEC	ZNRF1 →	+0.514	+3.021	<.001	<.001	3	2
UCEC	LONP1 →	+0.763	+3.010	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,638 associations by consensus.

RITA1 by OR5K1 expression — UCEC

Explore this box plot interactively →