Across TCGA pan-cancer cohorts, OR5K1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of OR5K1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where OR5K1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR5K1 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
KICH and LUSC are the cancer types where OR5K1 tumor–normal differential expression is most reproducible.