OR5K1

Across TCGA patient cohorts, OR5K1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR5K1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Cyclin-B1, and EGFR_pY1068. Each is linked with OR5K1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR5K1-to-partner and partner-to-OR5K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by OR5K1-low versus OR5K1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5K1→partner) and Y-score (partner→OR5K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.600	-3.584	.002	.002	2	3
UCEC	Cyclin-B1 →	+0.771	+3.169	.001	.019	3	2
UCEC	EGFR_pY1068 →	-0.277	-2.807	.011	.003	3	1
UCEC	eIF4E →	+0.191	+2.807	.038	.003	3	1
UCEC	MEK1 →	+0.433	+3.169	.006	.018	3	1
UCEC	MIG-6 →	+0.115	+2.820	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

p38-MAPK_pT180_Y182 by OR5K1 expression — UCEC

Explore this box plot interactively →