OR5K1

Across TCGA cell cohorts, OR5K1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible OR5K1-associated genes across cancer lineages are OR10R2, FAM71B, and GSTA3. Each is linked with OR5K1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR5K1-to-partner and partner-to-OR5K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10R2 grouped by OR5K1-low versus OR5K1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5K1→partner) and Y-score (partner→OR5K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10R2 →	+0.031	+4.977	<.001	.007	3	1
LUNG_SCLC	FAM71B →	+0.010	+4.058	<.001	.007	3	1
LUNG_SCLC	GSTA3 →	+0.050	+3.523	.002	.008	3	1
LUNG_SCLC	OR52D1 →	+0.064	+4.256	.006	.002	3	1
LUNG_SCLC	IFNL1 →	+0.117	+3.523	<.001	.008	3	1
LUNG_SCLC	SIGLEC12 →	+0.035	+4.459	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR10R2 by OR5K1 expression — LARGE_INTESTINE

Explore this box plot interactively →