OR5H8

Across TCGA pan-cancer cohorts, OR5H8 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of OR5H8’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where OR5H8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR5H8 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

LUSC, LIHC, and KIRC are the cancer types where OR5H8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OR5H8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	+0.070	<.001	5	view →
LIHC	All	All	+0.154	.002	3	view →
KIRC	All	All	−0.009	.013	3	view →
PRAD	All	All	+0.053	<.001	2	view →
LUAD	Female	All	+0.064	.049	1	view →
STAD	All	All	+0.028	.021	1	view →
KIRP	All	All	−0.018	.030	1	view →
KICH	All	All	−0.018	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

OR5H8–LUSC

Open the LUSC breakdown →