OR5H6

Across TCGA patient cohorts, OR5H6 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR5H6-associated genes across cancer lineages are Notch1, PCNA, and 4E-BP1. Each is linked with OR5H6 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR5H6-to-partner and partner-to-OR5H6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by OR5H6-low versus OR5H6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5H6→partner) and Y-score (partner→OR5H6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.167	+2.472	.004	.010	3	2
UCEC	PCNA →	+0.261	+2.584	.003	.010	3	2
UCEC	4E-BP1 →	+0.391	+2.321	<.001	.006	3	2
SKCM	GATA3 →	-0.151	-1.415	.035	.045	3	1
SKCM	HER3 →	+0.338	+2.459	.028	.018	3	1
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.527	+2.321	.010	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Notch1 by OR5H6 expression — UCEC

Explore this box plot interactively →