OR5C1

Across TCGA patient cohorts, OR5C1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR5C1-associated genes across cancer lineages are PDCD4, Rad50, and Caspase-7-cleavedD198. Each is linked with OR5C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR5C1-to-partner and partner-to-OR5C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by OR5C1-low versus OR5C1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5C1→partner) and Y-score (partner→OR5C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.758	-2.690	<.001	.006	3	2
UCEC	Rad50 →	-0.260	-1.700	.011	.044	3	2
UCEC	Caspase-7-cleavedD198 →	+0.635	+2.189	.011	.034	3	2
UCEC	CD20 →	+0.115	+1.894	.039	.030	3	2
COAD	PREX1 →	+0.299	+3.182	.003	.009	3	1
UCEC	eIF4E →	+0.189	+3.013	.034	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

PDCD4 by OR5C1 expression — UCEC

Explore this box plot interactively →