OR5B3

Across TCGA patient cohorts, OR5B3 mutation is significantly associated with the RNA expression of many other genes, with 558 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR5B3-associated genes across cancer lineages are HAUS8P1, PPM1G, and MAD2L2. Each is linked with OR5B3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR5B3-to-partner and partner-to-OR5B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAUS8P1 grouped by OR5B3-low versus OR5B3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5B3→partner) and Y-score (partner→OR5B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HAUS8P1 →	+0.026	+4.465	<.001	.003	3	2
SKCM	PPM1G →	+0.316	+1.604	.001	.006	3	2
SKCM	MAD2L2 →	+0.437	+2.776	.001	.002	3	2
UCEC	ZBTB17 →	+0.493	+3.459	.003	.005	3	2
UCEC	RNFT2 →	+0.769	+3.470	.001	.003	3	2
SKCM	CPSF4 →	+0.329	+2.738	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 558 associations by consensus.

HAUS8P1 by OR5B3 expression — LUAD

Explore this box plot interactively →