OR5B12

Across TCGA pan-cancer cohorts, OR5B12 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated OR5B12 data layer compared with 5 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher OR5B12 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OR5B12 expression acts as an unfavorable survival marker, although some lineages such as OV and SKCM show a favorable association.

UVM, OV, and SKCM are the cancer types where OR5B12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.260	0.815	<.001	72	view →
OV	OS	Tertile	All	0.766	0.645	.001	58	view →
SKCM	OS	Tertile	All	0.537	0.306	.002	51	view →
THYM	DFS	Quartile	All	0.737	0.965	.005	48	view →
SCLC	DFS	Tertile	IV	0.110	0.446	.010	36	view →
CHOL	DFS	Tertile	II,III,IV	0.807	0.144	.008	27	view →
LIHC	DFS	Tertile	All	0.409	0.552	.032	21	view →
LUSC	DFS	Tertile	All	0.893	0.653	.009	15	view →
LAML	DFS	Median	All	0.771	0.454	.001	14	view →
ACC	OS	Tertile	IV	0.344	0.724	.038	12	view →
MESO	OS	Quartile	IV	0.946	0.447	.009	12	view →
STAD	DFS	Quartile	II,III,IV	0.474	0.706	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

OR5B12–UVM (OS)

Open the UVM breakdown →