OR5AU1

Across TCGA patient cohorts, OR5AU1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR5AU1-associated genes across cancer lineages are EGFR, EGFR_pY1068, and Notch1. Each is linked with OR5AU1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR5AU1-to-partner and partner-to-OR5AU1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by OR5AU1-low versus OR5AU1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5AU1→partner) and Y-score (partner→OR5AU1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EGFR →	-0.177	-3.000	.029	.035	3	2
UCEC	EGFR_pY1068 →	-0.276	-3.321	.018	.010	3	1
UCEC	Notch1 →	+0.178	+2.179	.006	.034	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.452	-2.321	.031	.034	3	1
UCEC	Syk →	+0.347	+1.887	.047	.031	3	1
UCEC	TIGAR →	+0.161	+1.901	.023	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR by OR5AU1 expression — SKCM

Explore this box plot interactively →