OR56B4

Across TCGA patient cohorts, OR56B4 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR56B4-associated genes across cancer lineages are JNK2, Ku80, and Paxillin. Each is linked with OR56B4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR56B4-to-partner and partner-to-OR56B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by OR56B4-low versus OR56B4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR56B4→partner) and Y-score (partner→OR56B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.308	+3.026	.001	.018	3	1
UCEC	Ku80 →	+0.288	+3.598	.011	.001	3	1
UCEC	Paxillin →	+0.411	+3.179	.001	.010	3	1
UCEC	PDCD4 →	-0.777	-2.312	<.001	.034	3	1
UCEC	PKC-b-II_pS660 →	-0.276	-2.321	.038	.034	3	1
UCEC	VHL →	-0.937	-3.169	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

JNK2 by OR56B4 expression — UCEC

Explore this box plot interactively →