Across TCGA pan-cancer cohorts, OR52N5 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of OR52N5’s most consistent transcriptional readouts.
The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where OR52N5 RNA is repressed in tumor relative to normal tissue. In most cancer types OR52N5 is over-expressed in tumor, although a few such as PAAD and LUSC show the opposite, repressed pattern.
PAAD, LUSC, and LIHC are the cancer types where OR52N5 tumor–normal differential expression is most reproducible.