Across TCGA pan-cancer cohorts, OR52N1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of OR52N1’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where OR52N1 RNA is repressed in tumor relative to normal tissue. In most cancer types OR52N1 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
BRCA and LIHC are the cancer types where OR52N1 tumor–normal differential expression is most reproducible.