OR52D1

Across TCGA patient cohorts, OR52D1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR52D1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Smad3, and STAT3_pY705. Each is linked with OR52D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR52D1-to-partner and partner-to-OR52D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by OR52D1-low versus OR52D1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR52D1→partner) and Y-score (partner→OR52D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.463	-1.687	.015	.044	3	2
UCEC	Smad3 →	+0.179	+2.459	.005	.019	3	2
UCEC	STAT3_pY705 →	-0.419	-2.000	<.001	.029	3	2
UCEC	EGFR_pY1068 →	-0.275	-2.222	.009	.011	3	1
UCEC	FoxM1 →	+0.324	+4.000	.003	<.001	3	1
UCEC	INPP4B →	-0.431	-3.584	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

p38-MAPK_pT180_Y182 by OR52D1 expression — UCEC

Explore this box plot interactively →