Across TCGA pan-cancer cohorts, OR52D1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of OR52D1’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where OR52D1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR52D1 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.
BLCA and LUAD are the cancer types where OR52D1 tumor–normal differential expression is most reproducible.