OR51E2

Across TCGA patient cohorts, OR51E2 mutation is significantly associated with the RNA expression of many other genes, with 3,908 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR51E2-associated genes across cancer lineages are TRIB3, LRRC59, and TMEM104. Each is linked with OR51E2 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR51E2-to-partner and partner-to-OR51E2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIB3 grouped by OR51E2-low versus OR51E2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR51E2→partner) and Y-score (partner→OR51E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRIB3 →	+0.899	+2.502	<.001	.001	3	3
UCEC	LRRC59 →	+0.467	+3.043	<.001	<.001	3	3
SKCM	TMEM104 →	+0.347	+3.019	.004	<.001	3	3
UCEC	MTRF1L →	+0.403	+2.513	<.001	<.001	3	3
SKCM	COPB1 →	+0.427	+1.828	.009	.006	3	3
SKCM	RNF126 →	+0.366	+3.025	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,908 associations by consensus.

TRIB3 by OR51E2 expression — UCEC

Explore this box plot interactively →