OR51E2

Across TCGA patient cohorts, OR51E2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR51E2-associated genes across cancer lineages are SF2, p62 Lck ligand, and Annexin-1. Each is linked with OR51E2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR51E2-to-partner and partner-to-OR51E2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SF2 grouped by OR51E2-low versus OR51E2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR51E2→partner) and Y-score (partner→OR51E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SF2 →	+0.120	+1.415	.019	.045	3	2
UCEC	p62 Lck ligand →	+0.432	+2.584	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.365	+1.720	.038	.025	3	2
UCEC	STAT3_pY705 →	-0.320	-1.492	<.001	.027	3	2
UCEC	TFRC →	+0.473	+3.700	.007	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.532	+1.505	.007	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

SF2 by OR51E2 expression — SKCM

Explore this box plot interactively →