OR51E2

Across TCGA cell cohorts, OR51E2 mutation is significantly associated with the RNA expression of many other genes, with 799 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR51E2-associated genes across cancer lineages are PRAMEF17, PRAMEF10, and PRAMEF20. Each is linked with OR51E2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR51E2-to-partner and partner-to-OR51E2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF17 grouped by OR51E2-low versus OR51E2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR51E2→partner) and Y-score (partner→OR51E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	2
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF20 →	+0.367	+4.269	<.001	.005	3	1
LUNG_SCLC	GSTT4 →	+0.011	+4.269	.002	.005	3	1
LUNG_SCLC	OR13C5 →	+0.045	+4.817	<.001	.001	3	1
LARGE_INTESTINE	EIF3L →	+0.476	+2.628	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 799 associations by consensus.

PRAMEF17 by OR51E2 expression — LUNG_SCLC

Explore this box plot interactively →