OR4X2

Across TCGA patient cohorts, OR4X2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR4X2-associated genes across cancer lineages are MYH11, p38-MAPK_pT180_Y182, and VHL. Each is linked with OR4X2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4X2-to-partner and partner-to-OR4X2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH11 grouped by OR4X2-low versus OR4X2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4X2→partner) and Y-score (partner→OR4X2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MYH11 →	-0.657	-2.700	.030	.005	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.347	-2.222	.004	.009	3	2
SKCM	VHL →	-0.496	-1.874	.040	.047	3	2
SKCM	4E-BP1 →	+0.257	+1.485	.016	.049	3	2
UCEC	TFRC →	+0.618	+2.999	.020	.035	3	2
SKCM	eIF4G →	+0.299	+1.999	.032	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MYH11 by OR4X2 expression — SKCM

Explore this box plot interactively →