OR4S1

Across TCGA patient cohorts, OR4S1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4S1-associated genes across cancer lineages are cIAP, JNK_pT183_Y185, and FASN. Each is linked with OR4S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4S1-to-partner and partner-to-OR4S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, cIAP grouped by OR4S1-low versus OR4S1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4S1→partner) and Y-score (partner→OR4S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	cIAP →	+0.184	+2.817	.014	.036	3	2
UCEC	JNK_pT183_Y185 →	-0.226	-3.156	.014	.020	3	1
SKCM	FASN →	-0.436	-2.700	.046	.006	3	1
SKCM	SF2 →	-0.134	-2.000	.029	.031	3	1
UCEC	ATM →	-0.777	-3.169	.001	.020	1	2
UCEC	Di-Ras3 →	-0.223	-3.169	.006	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

cIAP by OR4S1 expression — UCEC

Explore this box plot interactively →