OR4S1

Across TCGA pan-cancer cohorts, OR4S1 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated OR4S1 data layer compared with 4 for mutation status.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher OR4S1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OR4S1 expression acts as an unfavorable survival marker, although some lineages such as ESCA show a favorable association.

STAD, SKCM, and DLBC are the cancer types where OR4S1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	All	0.121	0.548	<.001	72	view →
SKCM	OS	Tertile	All	0.398	0.791	<.001	72	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	36	view →
KIRC	DFS	Tertile	IV	0.114	0.640	.002	36	view →
LUSC	OS	Tertile	All	0.264	0.728	.004	36	view →
LGG	OS	Tertile	All	0.577	0.818	<.001	27	view →
BLCA	OS	Tertile	III,IV	0.228	0.684	.023	18	view →
GBM	OS	Tertile	All	0.030	0.416	<.001	18	view →
ESCA	DFS	Tertile	III,IV	0.666	0.279	.045	6	view →
SARC	OS	Tertile	All	0.236	0.601	.046	6	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

OR4S1–STAD (DFS)

Open the STAD breakdown →